Summary of study comparing specific genotype in elite and sub-elite Olympic weightlifters with their weightlifting performance.
153 Olympic weightlifters:
- 53 elite weightlifters (22 females, 31 males; aged 23.3±4.1 years; Russian) and
- 100 sub-elite weightlifters (47 females, 53 males; aged 21.4±4.2 years; Japanese).
- snatch and clean & jerk performance (total in kg multiplied by Wilks coefficient)
- polygenetic score (based on 28 DNA polymorphisms)
- polygenetic score positively correlated with weightlifting performance.
- carriers of the high number of strength-related alleles (27-34) had better weightlifting results than carriers of the low number of strength-related allels (20-26).
- specific alleles that correlated with performance are: LRPPRC rs10186876 A, MMS22L rs9320823 T, MTHFR rs1801131 C, and PHACTR1 rs6905419 C.
- carriers of a high (6-8) number of strength-related alleles had better weightlifting results than carriers of a low (0-5) number of strength-related alleles.
- specific alleles that correlated with performance: only MMS22L rs9320823 T.
- carriers of a high number of strength-related alleles were stronger than carriers of a low number of strength-related alleles.
Take home message
Kikuchi N, Moreland E, Homma H, Semenova EA, Saito M, Larin AK, Kobatake N, Yusupov RA, Okamoto T, Nakazato K, Williams AG. Genes and Weightlifting Performance. Genes. 2021 Dec 23;13(1):25.